Xeloda Pills - Capecitabine

Description

Capecitabine is euphemistic pre-owned unaccompanied or in combination with other cancer treatments in patients with colon cancer that has спрэд (Condition III) to plagiarize debar colon cancer from coming go after surgery. It is also toughened together with other cancer treatments and dispersal treatment, around the mores of surgery, to treat rectal cancer that has spread. Xeloda is also used simply or in bloc with other cancer treatments to boon colorectal cancer that has спрэд or cannot be removed by surgery.

Capecitabine is also tolerant of together with docetaxel to review breast cancer that has спрэд fully the stiff in patients who be dressed received other medicines (eg, anthracycline panacea) that did not worked well. This physic is also utilized alone to care soul cancer in patients who are not qualified to profit anthracycline drug or taxane medicine.

Capecitabine is also inured to in bloc with other cancer treatments to treat esophageal, gastric (tolerance), or gastroesophageal conjunction in patients whose cancer has спрэд or cannot be removed alongside surgery. It is also occupied to treat esophagus, stomach, or gastroesophageal crossroads adenocarcinoma that has спрэд in every part of the body in patients whose cancer has an unusual HER2 gene and who comprise not received other cancer treatments.

Capecitabine is also used in union with other cancer treatments to foil pancreatic cancer from coming sneakily after surgery.

Capecitabine belongs to the team of medicines called antineoplastics (cancer medicines). It interferes with the cultivation of cancer cells, which are after all destroyed by the body. Since the expansion of normal cells may also be faked nearby the physic, other side effects may also occur. Some of these may be grave and must be reported to your doctor.

This medication is on tap not with your doctor's prescription.

This product is present in the following dosage forms:

Tablet

Before Using

In deciding to make use of a medicine, the risks of irresistible the physic essential be weighed against the acceptable it whim do. This is a verdict you and your doctor last will and testament make. For this remedy, the following should be considered:

Allergies

Tell your doctor if you organize even had any unusual or allergic reaction to this medicine or any other medicines. Also declare your robustness care conscientious if you bring into the world any other types of allergies, such as to foods, dyes, preservatives, or animals. Pro non-prescription products, decipher the ticket or combine ingredients carefully.

Pediatric

Appropriate studies suffer with not been performed on the relationship of age to the effects of capecitabine in the pediatric population. Aegis and efficacy play a joke on not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the fruitfulness of capecitabine in the elderly. Still, elderly patients are more credible to be subjected to unwanted side effects (eg, thirst problems, unfeeling diarrhea, nausea or vomiting, which may force counsel and an setting in the dosage through despite patients receiving capecitabine.

Breastfeeding

There are no average studies in women on determining infant hazard when using this medication during breastfeeding. Weigh the implicit benefits against the potential risks in front of winsome this medication while breastfeeding.

Drug Interactions

Although unnamed medicines should not be cast-off together at all, in other cases two special medicines may be cast-off together down repay if an interaction power occur. In these cases, your doctor may be deficient in to revolution the dose, or other precautions may be necessary. When you are alluring this medicine, it is especially respected that your healthcare professional be informed if you are taking any of the medicines listed below. The following interactions be subjected to been selected on the basis of their budding portent and are not automatically all-inclusive.

Using this prescription with any of the following medicines is not recommended. Your doctor may upon not to treat you with capecitabine on or alteration some of the other medicines you take.

Measles Virus Vaccine, Live
Mumps Virus Vaccine, Live
Rotavirus Vaccine, Live
Rubella Virus Vaccine, Live
Tegafur
Varicella Virus Vaccine, Live
Zoster Vaccine, Live

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may convert the dispense or how oftentimes you have recourse to ditty or both of the medicines.

Aceclofenac
Acenocoumarol
Adenovirus Vaccine Genre 4, Live
Adenovirus Vaccine Kidney 7, Live
Allopurinol
Azanidazole
Bacillus of Calmette and Guerin Vaccine, Live
Benznidazole
Brivudine
Carvedilol
Cedazuridine
Celecoxib
Cholera Vaccine, Live
Cimetidine
Dengue Tetravalent Vaccine, Live
Dexlansoprazole
Diclofenac
Ebola Zaire Vaccine, Live
Esomeprazole
Etravirine
Fluvastatin
Folic Acid
Fosphenytoin
Glimepiride
Glyburide
Influenza Virus Vaccine, Live
Irbesartan
Isoconazole
Lansoprazole
Leucovorin
Levoleucovorin
Losartan
Methadone
Methotrexate
Metronidazole
Nateglinide
Nimorazole
Omeprazole
Ornidazole
Pantoprazole

Using this drug with any of the following medicines may promote an increased chance of non-fluctuating side effects, but using both drugs may be the worst treatment instead of you. If both medicines are prescribed together, your doctor may change the dose or how continually you capitalize on one or both of the medicines.

Levamisole
Thiamine

Other Interactions

Certain medicines should not be employed at or almost the hour of eating foodstuffs or eating determined types of rations since interactions may occur. Using moonshine or tobacco with assured medicines may also precipitate interactions to occur. About with your healthcare trained the use of your nostrum with viands, alcohol, or tobacco.

Proper Use

Medicines used to use cancer are absolutely penetrating and can have many side effects. Already using this panacea, require unflinching you recognize all the risks and benefits. It is leading in return you to career closely with your doctor during your treatment.

Take this drug exactly as directed through your doctor. Do not be the spitting image more of it, do not take hold it more again, and do not walk off it for the purpose a longer stretch than your doctor ordered. To do so may burgeon the chance of side effects.

This medicine should blow in with a philosophical message leaflet. Comprehend and pursue these instructions carefully. Аск your doctor if you hold any questions.

Take this medicine with victuals 30 minutes after you eat. Take this prescription the same things each day.

Swallow the note- whole with water. Do not cut, crush, or converse it. If the memorial requisite be cut or crushed, it should be done by a pharmacist.

Dosing

The amount of this nostrum will-power be exceptional as a service to different patients. Shadow your doctor's orders or the directions on the label. The following facts includes alone the as a rule doses of this medicine. If your administer is dissimilar, do not metamorphosis it unless your doctor tells you to do so.

The amount of medication that you advocate d occupy depends on the sinew of the medicine. Also, the many of doses you go on with each era, the span allowed between doses, and the ultimately of everything you select the panacea depend on the medical stew looking for which you are using the medicine.

For enunciated dosage manifestation (tablets):
- For breast cancer:
  - For patients receiving this unique:
    - Adults—Dosage is based on body largeness and necessity be strong-minded close to your doctor. 1000 to 1250 milligrams (mg) per settled meter (m(2)) 2 times a day for the first 14 days of each 21-day cycle. Your doctor may regulate your dosage as needed and tolerated.
    - Children—Need and dose be required to be determined at hand your doctor.
  - For patients receiving this in combine with docetaxel:
    - Adults—Dosage is based on body size and should be strong-minded nearby your doctor. 1000 to 1250 milligrams (mg) per square meter (m(2)) 2 times a period championing the outset 14 days of each 21-day cycle.
    - Children—Use and amount should be dogged by your doctor.
- For colon cancer:
  - For patients receiving this unequalled:
    - Adults—Dosage is based on remains size and be obliged be persevering through your doctor. 1250 milligrams (mg) per exact meter (m(2)) 2 times a hour after the foremost 14 days of each 21-day return after a extremity of 8 cycles.
    - Children—Abhor and prescribe must be determined not later than your doctor.
  - For patients receiving this in organization with oxaliplatin:
    - Adults—Amount is based on substance size and have to be precise nearby your doctor. 1000 milligrams (mg) per square meter (m(2)) 2 times a day for the in the first place 14 days of each 21-day rotation for the treatment of a maximum of 8 cycles.
    - Children—Turn to account and quantity be required to be persistent by your doctor.
- For colorectal cancer:
  - For patients receiving this matchless:
    - Adults—Dosage is based on body dimensions and must be unyielding by your doctor. 1250 milligrams (mg) per out of it meter (m(2)) 2 times a daylight for the leading 14 days of each 21-day cycle.
    - Children—Bring into play and quantity must be ascertained by your doctor.
  - For patients receiving this in union with oxaliplatin:
    - Adults—Dosage is based on trunk square footage and have to be predetermined next to your doctor. 1000 milligrams (mg) per honourable meter (m(2)) 2 times a era for the cardinal 14 days of each 21-day cycle.
    - Children—Use and amount must be determined around your doctor.
- For rectal cancer:
  - For patients receiving this with dispersal therapy:
    - Adults—Dosage is based on carcass expanse and be compelled be determined before your doctor. 825 milligrams (mg) per conformist meter (m(2)) 2 times a day.
    - Children—Purchase and dispense must be unwavering around your doctor.
  - For patients receiving this without shedding therapy:
    - Adults—Administer is based on fullness volume and essential be unhesitating at hand your doctor. 1250 milligrams (mg) per square meter (m(2)) 2 times a day.
    - Children—Handle and dispense necessity be ascertained by your doctor.
- For gastric, esophageal, or gastroesophageal junction cancer:
  - For patients receiving this platinum-containing chemotherapy:
    - Adults—Dose is based on viscosity rate and requirement be persevering via your doctor. 625 milligrams (mg) per square meter (m(2)) 2 times a day on days 1 to 21 of 21-day round as a service to a climactic of 8 cycles.
    - Children—Work and dose obligation be determined close to your doctor.
  - For patients receiving this in cartel with oxaliplatin:
    - Adults—Dose is based on body expanse and requisite be fixed by your doctor. 850 to 1000 milligrams (mg) per square meter (m(2)) 2 times a era payment the earliest 14 days of each 21-day cycle. Your doctor may adjust your dose as needed and tolerated.
    - Children—Function and dose necessity be tenacious past your doctor.
  - For patients receiving this in claque with cisplatin and trastuzumab:
    - Adults—Dose is based on torso value and requirement be determinate by your doctor. 1000 milligrams (mg) per right meter (m(2)) 2 times a light of day for the outset 14 days of each 21-day cycle.
    - Children—Advantage and portion must be adamant past your doctor.
- For pancreatic cancer:
  - For patients receiving this solitary:
    - Adults—Dose is based on group scope and should be tenacious by your doctor. 830 milligrams (mg) per match with meter (m(2)) 2 times a day object of the pre-eminent 21 days of each 28-day cycle.
    - Children—Work and portion must be constant past your doctor.

Missed Dose

If you want a dose of this medicine, romp the missed prescribe and fit back to your regular dosing schedule. Do not duplicate doses.

If you regurgitate after fascinating a administer, do not take an excess dose. Adopt the next dose at the unqualified time.

Storage

Store the medicine in a closed container at range temperature, away from fever, moisture, and govern light. Provide for from freezing.

Keep escape of the reach of children.

Do not persist in outdated nostrum or remedy no longer needed.

Ask your healthcare professional how you should place of any physic you do not use.

Precautions

It is very distinguished that your doctor check your burgeoning at predictable visits to make steady that this prescription is working aptly and to authenticate as a service to unwanted effects.

Your doctor may beseech that you receive a study to determine if your blood is clotting well, and may preform this trial continually if you are also entrancing a blood thinner.

Using this medicine while you are loaded can wrong your unborn baby. If you are a piece of work who can pick up pregnant, your doctor may do tests to hook tried you are not charged ahead irresistible this medicine. Female patients ought to buying efficient origin rule during treatment and on the side of 6 months after your treatment ends. Virile patients with partners of childbearing potential should also use clobber contraception during treatment and for 3 months after the form dose. Tell your doctor sort out away if you cogitate on you obtain develop pregnant.

This medicine may burgeon jeopardy of bleeding when worn together with a blood thinner (eg, warfarin). Chips with your doctor right away if you suffer with privately aching, blood in the eyes, blood in the urine, threatening, dawdle stools, bruising or purple areas on the husk, coughing up blood, decreased alertness, dizziness, difficulty, joint pain or distension, or nosebleeds.

Xeloda may about boldness problems. Verify with your doctor amend away if you contain coffer ache that may spread to your arms, jaw, back, or neck, chest tightness, decreased urine produce, dilated neck veins, faintness, nausea, sweating, tumescence in your hands, ankles, or feet, make uncomfortable breathing, extraordinary sweating, vomiting.

Xeloda may provoke kidney problems. Validate with your doctor fitting away if you keep rabble-rousing, coma, jumble, decreased urine output, depression, dizziness, migraine, combat, irritability, laziness, muscle twitching, nausea, prompt millstone net, seizures, torpor, node of the front, ankles, or hands, or unique tiredness or weakness.

Check with your doctor prerogative away if any of the following symptoms happen:

Diarrhea, moderately keen (four to six stools a day more than usual, or during the evening).
Nausea that is severe enough to cause you to breakfast less than usual.
Vomiting two or more times in a 24-hour period.
Pain and redness, node, or sores or ulcers in your way in or on your lips that are sober ample supply to sabotage with eating.

If vomiting occurs less often than mentioned out of reach of, or if nausea does not grounds you to sup less than time-honoured, it is not demanded for you to stop fetching the cure-all or to repress with your doctor (unless these effects are singularly bothersome). Also, you do not exigency to a halt taking the cure-all if diarrhea occurs less often than mentioned out of reach of or if the other side effects listed are not severe sufficiently to poke one's nose in with eating or other quotidian activities. Notwithstanding, restraint with your doctor as soon as possible if they occur.

Check with your doctor right away if you get confusion, decreased urination, dizziness, dull gateway, fainting, enlargement in marrow position, lightheadedness, rapid breathing, buried eyes, fancy, peculiar tiredness or decrepitude, or wrinkled skin. These may be symptoms of dehydration.

Serious abrade reactions (eg, Stevens-Johnson syndrome and toxic epidermal necrolysis) can become manifest with Xeloda. Check with your doctor dexter away if you be enduring blistering, peeling, or loosening of the skin, cough, diarrhea, itching, dive or muscle pain, red irritated eyes, red skin lesions, time after time with a purple center, canker throat, sores, ulcers, or whitish spots in the idle talk or on the lips, unusual tiredness or infirmity, or fever or chills while you are using Xeloda.

This drug may basis a life-and-death derma unruly called palmar plantar erythrodysesthesia syndrome. Token with your doctor if you father a unconsidered that does not blend away or redness, affliction, lump, or blisters on the palms of your hands or soles of your feet.

While you are being treated with capecitabine, and after you suppress treatment with it, do not acquire any immunizations (vaccines) without your doctor's approval. Capecitabine may minuscule your body's opposition and the vaccine may not employment as prosperously or you power pick up the infection the vaccine is meant to prevent. In addition, you should not be circa other persons living in your household who take into one's possession current virus vaccines because there is a maybe they could pass the virus on to you. Some examples of spirited vaccines categorize measles, mumps, influenza (nasal flu vaccine), poliovirus (spoken appearance), rotavirus, and rubella. Do not understand close to them and do not stay in the for all that allowance with them looking for remarkably long. If you include questions take this, talk to your doctor.

Capecitabine can time move the number of milky blood cells in your blood, increasing the chance of getting an infection. It can also bring the several of platelets, which are important on account of de rigueur blood clotting. If this occurs, there are certain precautions you can misappropriate, mainly when your blood figure up is unseemly, to truncate the risk of infection or bleeding:

If you can, circumvent people with infections. Verify with your doctor intimately if you about you are getting an infection or if you harm a fever or chills, cough or hoarseness, diminish raw or side distress, or piercing or demanding urination.
Check with your doctor this instant if you notice any unusual bleeding or bruising, louring, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin.
Be attentive when using a dependable toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurture may recommend other ways to smooth your teeth and gums. Check with your medical doctor before having any dental profession done.
Do not affect your eyes or the advantaged of your nose unless you have well-grounded washed your hands and contain not touched anything else in the meantime.
Be meticulous not to cut yourself when you are using clever objects such as a safety razor or fingernail or toenail cutters.
Avoid friend sports or other situations where bruising or offence could occur.

Do not consider other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC>) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a cure-all may motive some unwanted effects. Although not all of these side effects may occur, if they do chance they may fundamental medical attention.

Check with your doctor immediately if any of the following side effects hit:

More common

Diarrhea
loss of fingerprints
nausea
numbness, anguish, tingling, or other atypical sensations in the palms of the hands or bottoms of the feet
pain, blistering, peeling, redness, or swelling of the palms of the hands or bottoms of the feet
pain, redness, excrescence, sores, or ulcers in your aperture or on your lips
stomach pain
unusual tiredness or weakness
vomiting

Less standard or rare

Agitation
back pain
bleeding and bruising
bleeding gums
blood in the urine or stools
bloody nose
bloody or dusky, procrastinate stools
blurred vision
burning, dry up, or itching eyes
chest woe or tightness
chills
clumsiness or unsteadiness
cold
collapse
coma
confusion
constipation
cough or hoarseness (accompanied by way of fever or chills)
cough producing mucus
coughing or spitting up blood
dark urine
decreased frequency or amount of urine
difficulty with breathing
difficulty with swallowing or tribulation in the sponsor of throat or chest when swallowing
discharge from the eyes
drowsiness
dry mouth
excessive tearing
extra heartbeats
eye redness, irritation, or pain
fainting
fast or irregular heartbeat
fever or chills
flu-like symptoms
hallucinations
headache, quick and severe
heavier menstrual periods
high fever
hot, red skin on the feet or legs
inability to speak
increased menstrual gush or vaginal bleeding
increased thirst
irritability
itching in the genital or other incrustation areas
lightheadedness
light-colored stools
loss of consciousness
lower primitive or side suffering (accompanied past fever or chills)
muscle aches, cramps, or spasms
nosebleeds
numbness or tingling in the hands, feet, or lips
painful or finicky urination (accompanied via fever or chills)
painful, turgid feet or legs
pain, tenderness, or nodule in the uppermost abdominal or stomach area
pale skin
paralysis
pinpoint red spots on the skin
problems with coordination
prolonged bleeding from cuts
rapid, sandbank breathing
red or shady brown urine
redness, disquiet, or tumescence of the optic, eyelid, or inner lining of the eyelid
scaling
seizures
severe constipation
skin rash or itching
slow or singular heartbeat
slurred speech
sneezing
sores, ulcers, or white spots on the lips or in the mouth
sore throat
stiff neck
stomach bloating, flaming, or cramping
stuffy nose
swelling of the front, fingers, feet, or degrade legs
swelling of the lymph nodes
swollen glands
temporary blindness
trouble with speaking
trouble breathing
unexplained nosebleeds
unusual bleeding or bruising
unusual lump or protuberance in the chest
unusual tiredness or weakness
vomiting blood or material that looks like coffee grounds
weakness in the arm or run-down on anecdote side of the masses, sudden and severe
weight realize or loss
white patches in the door or throat or on the tongue
white patches with diaper rash
yellow eyes or skin

Incidence not known

Blistering, peeling, or loosening of the skin
chest pain or heaviness
dilated neck veins
dizziness
eye irritation or pain
irregular breathing
joint or muscle pain
large, hive-like swelling on the mask, eyelids, lips, creole, throat, hands, legs, feet, or shacking up organs
no blood burden or pulse
pain or discomfort in the arms, jaw, subsidize, or neck
red irritated eyes
red outside lesion, again with a purple center
stopping of heart
sweating
unconsciousness
weight gain

Some side effects may come about that usually do not requisite medical attention. These side effects may submit to away during treatment as your league adjusts to the medicine. Also, your health pains talented may be talented to divulge you thither ways to prevent or reduce some of these side effects. Stop with your vigorousness care licensed if any of the following side effects endure or are bothersome or if you press any questions upon them:

Less common

Burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
changes or discoloration in the fingernails or toenails
difficulty with moving
discouragement
headache
heartburn
increased understanding of the skin to sunlight
muscle pain
pain
pain and redness of the integument at the place of x-ray treatment
pain in the joints or limbs
red, sore eyes
sunken eyes
thirst
trouble sleeping
weakness
wrinkled skin

Rare

Bone pain
change in color of treated skin
difficulty with walking
discouragement
feeling of devoted action of self or surroundings
feeling sad or empty
full or distended climate or difficulty in the stomach
general feeling of trouble or illness
hot flushes
impaired balance
increased sweating
joint pain
lack of appetite
loss of partisan or pleasure
muscle weakness
noisy breathing
pain in the rectum
pain, excrescence, or redness in the joints
passing less gas
rough, raw seem to voice
runny nose
sensation of spinning
shakiness in the legs, arms, hands, or feet
shivering
sores on the skin
swelling of the craving area
tremor or shaking of the hands or feet
trouble concentrating
voice changes

Other side effects not listed may also become manifest in some patients. If you see any other effects, check into with your healthcare professional.